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Macosko Lab

Macosko Lab

Nervous system biology through innovative genomics

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Selected Papers

 

Russell AJC, Weir JA, Nadaf NM, Shabet M, Kumar V, Kambhampati S, Raichur R, Marrero GJ, Liu S, Balderrama KS, Vanderburg CR, Shanmugam V, Tian L, Iorgulescu JB, Yoon CH, Wu CJ, Macosko EZ*, Chen F*.  “Slide-tags enables single-nucleus barcoding for mutlimodal spatial genomics.”  Nature.  2024

 

 

Langlieb J, Sachdev NS, Balderrama KS, Nadaf NM, Raj M, Murray E, Webber JT, Vanderburg C, Gazestani V, Tward D, Mezias C, Li X, Flowers K, Cable DM, Norton T, Mitra P, Chen F*, Macosko EZ*. “The molecular cytoarchitecture of the adult mouse brain.” Nature. 2023 

 

Gazestani V, Kamath T, Nadaf NM, Dougalis A, Burris SJ, Rooney B, Junkkari A, Vanderburg C, Pelkonen A, Gomez-Budia M, Välimäki NN, Rauramaa T, Therrien M, Koivisto AM, Tegtmeyer M, Herukka SK, Abdulraouf A, Marsh SE, Hiltunen M, Nehme R, Malm T, Stevens B, Leinonen V, Macosko EZ. “Early Alzheimer’s disease pathology in human cortex involves transient cell states.” Cell. 2023

 

 

Tian L, Chen F, Macosko EZ. “The expanding vistas of spatial transcriptomics.” Nat Biotechnol. 2023

 

 

Kamath T, Abdulraouf A, Burris SJ, Langlieb J, Gazestani V, Nadaf NM, Balderrama K, Vanderburg C, Macosko EZ. “Single-cell genomic profiling of human dopamine neurons identifies a population that selectively degenerates in Parkinson’s disease.” Nat Neurosci. 2022 
Kamath T, Abdulraouf  A, Burris SJ, Gazestani V, Nadaf N, Vanderburg V, Macosko EZ. “A molecular census of midbrain dopaminergic neurons in Parkinson’s disease.” Biorxiv 2021.
Kozareva V*, Martin C, Osorno T, Rudolph S, Guo C, Vanderburg C, Nadaf N, Regev A, Regehr W, Macosko E. “A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types.” Nature 2021, 598, 214-235.
Stickels RR, Murray E, Kumar P, Li J, Marshall JL, Di Bella DJ, Arlotta P, Macosko EZ**, Chen F**. “Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2.” Nature Biotechnology 2021, 39, 313-319.

Welch JD, Kozareva V, Ferreira A, Vanderburg CR, Martin CA, Macosko EZ. “Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity.” Cell 2019, 177, 1873-1887.
Rodriques SG*, Stickels RR*, Goeva A, Martin CA, Murray E, Vanderburg CR, Welch J, Chen LM, Chen F**, Macosko EZ**. “Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution.” Science 2019, 363, 1463-1467.
Saunders A*, Macosko EZ*, Wysoker A, Goldman M, Krienen FM, de Rivera H, Bien E, Baum M, Bortolin L, Wang S, Goeva A, Nemesh J, Kamitaki N, Brumbaugh S, Kulp D, McCarroll SA. “Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain.” Cell 2018, 174, 1015–1030.
Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT. “A molecular census of arcuate hypothalamus
and median eminence cell types.” Nature Neuroscience 2017, 20, 484-496.
macosko2015-1
Macosko E*, Basu A, Satija R, Nemesh J, Shekhar K, Goldman M, Tirosh I, Bialas, A, Kamitaki N, Martersteck E, Trombetta J, Weitz D, Sanes J, Shalek A, Regev A, McCarroll S*. “Highly Parallel Genome-Wide Expression Profiling of Individual cells Using Nanoliter Droplets.” Cell 2015, 161, 1202-1214. *Co-corresponding authors

What we’re working on

Read about Slide-tags, our new approach that unifies single-cell and spatial genomics.

 

Explore the first comprehensive cell atlas of a mammalian brain.  Stay tuned for the human next!

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