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Macosko Lab

Macosko Lab

Nervous system biology through innovative genomics

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Papers

Kamath T, Abdulraouf  A, Burris SJ, Gazestani V, Nadaf N, Vanderburg V, Macosko EZ. “A molecular census of midbrain dopaminergic neurons in Parkinson’s disease.” Biorxiv 2021.
Kozareva V*, Martin C, Osorno T, Rudolph S, Guo C, Vanderburg C, Nadaf N, Regev A, Regehr W, Macosko E. “A transcriptomic atlas of mouse cerebellar cortex comprehensively defines cell types.” Nature 2021, 598, 214-235.
Stickels RR, Murray E, Kumar P, Li J, Marshall JL, Di Bella DJ, Arlotta P, Macosko EZ**, Chen F**. “Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2.” Nature Biotechnology 2021, 39, 313-319.

Welch JD, Kozareva V, Ferreira A, Vanderburg CR, Martin CA, Macosko EZ. “Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity.” Cell 2019, 177, 1873-1887.
Rodriques SG*, Stickels RR*, Goeva A, Martin CA, Murray E, Vanderburg CR, Welch J, Chen LM, Chen F**, Macosko EZ**. “Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution.” Science 2019, 363, 1463-1467.
Saunders A*, Macosko EZ*, Wysoker A, Goldman M, Krienen FM, de Rivera H, Bien E, Baum M, Bortolin L, Wang S, Goeva A, Nemesh J, Kamitaki N, Brumbaugh S, Kulp D, McCarroll SA. “Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain.” Cell 2018, 174, 1015–1030.
Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, Goldman M, Verstegen AM, Resch JM, McCarroll SA, Rosen ED, Lowell BB, Tsai LT. “A molecular census of arcuate hypothalamus
and median eminence cell types.” Nature Neuroscience 2017, 20, 484-496.
macosko2015-1
Macosko E*, Basu A, Satija R, Nemesh J, Shekhar K, Goldman M, Tirosh I, Bialas, A, Kamitaki N, Martersteck E, Trombetta J, Weitz D, Sanes J, Shalek A, Regev A, McCarroll S*. “Highly Parallel Genome-Wide Expression Profiling of Individual cells Using Nanoliter Droplets.” Cell 2015, 161, 1202-1214. *Co-corresponding authors

What we’re working on

Latest news from the Macosko Lab

Read about Slide-seq, our highly scalable technology for measuring spatial transcriptomes at cellular resolution!

 

Check out LIGER, our new software package for integrating and analyzing single cell datasets!

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